Aspirin TLC Plate Making Chromatography Visible

Thin layer chromatography (TLC) is one of the most widely used techniques in chemistry, but for many students it remains abstract; something seen briefly in a lab, then quickly forgotten.

This 3D printed model changes that!

Designed as a tactile lithophane, this TLC plate brings the synthesis of aspirin to life in a way that can be both felt and seen. The surface features the familiar elements of a chromatogram (baseline, solvent front, and labelled lanes) all raised so they can be traced by hand.

But the real effect appears when light is introduced.

Hold the model up to a light source, and the chromatogram is revealed. The separated spots emerge just as they would on a real TLC plate, mimicking the way chemists visualise compounds after development.

The plate represents a typical aspirin synthesis:

• A – the starting material, 2-hydroxybenzoic acid

• B – the crude reaction mixture (a combination of starting material and aspirin)

• C – the purified product, aspirin

This progression allows students to clearly see how a reaction is monitored and how purification improves the final product.

Why this works

By combining a physical model with a backlit image, this design bridges the gap between theory and practice. It removes the need for chemicals, UV lamps, or lab access, while still capturing the essence of the technique.

It’s particularly effective for:

• explaining reaction monitoring

• introducing chromatography concepts

• supporting visual and tactile learners

• outreach and public engagement

Using the model

Print in a light-coloured filament for best results. To reveal the chromatogram, simply shine a light (such as a phone torch) from behind.

Materials

This model was printed using Bambu PLA Basic in Magenta, Jade White, Cyan, and Yellow. These colours help emphasise the chromatogram when backlit, but any light-coloured filament can be used to achieve the lithophane effect.

Download & Print

You can download and print the model from:

• Printables

• MakerWorld

A simple idea, made tangible

Chemistry is often taught through diagrams and fleeting experiments. This model turns one of those diagrams into something permanent; something you can hold, explore, and return to.